Leprosy: Awakening the unresponsive lymphocyte
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چکیده
منابع مشابه
The lymphocyte and resistance to leprosy.
"How soon can I discover if it docs?" Statistically valid data may confirm or re fute early clinical inipress ions. Good public relations may 1)(' fostcred if the investigator can communicate direc tly with his patients in their O\vn language. The more he knows of local customs and beliefs about leprosy, the better; he may be saved from committing faux 1J([oS', and may learn much, for ins'tance...
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We have demonstrated that allograft immunity is impaired in leprosy patients, especially patients with lepromatous leprosy ( 4). This finding indicates that the lymphocytes of leprosy patients are immunologically defective with respect to their activities in vivo, a concept which is supported by the in vitro work of others on lymphocyte transformation (2, 3, 8), and our recent work on lymphotox...
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Awakening heterochromatin ites in the human genome once thought to be inert structural material are brought to life in response to stress, according to results from Jolly et al. (page 25). These inactive DNA stretches are binding sites for HSF1, a transcription factor that activates individual heat shock genes and accumulates in nuclear granules after heat shock. These granules were, like HSF1,...
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Untreated leprosy patients were examined with respect to lymphocyte transformation in vitro after stimulation with mycobacterial and other microbial antigens, allogeneic lymphocytes, or nonspecific mitogens. Methods were used to circumvent technical variability. The results were compared with those obtained in controls matched for age, sex, race, and environment. No evidence was found for a gen...
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ژورنال
عنوان ژورنال: Nature
سال: 1983
ISSN: 0028-0836,1476-4687
DOI: 10.1038/303284a0